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Selective Synthesis of Functionally Substituted 1,2,3-Triazoles

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Abstract

Different conditions were used to achieve selective formation of 4.5-disubstituted 1-aryl(hetaryl)-1,2,3-triazoles via cycloaddition of the corresponding enolates and aryl or hetaryl azides. Optimal conditions were found for the bromination of 1-(5-methyl-1-phenyl-1,2,3-triazol-4-yl)ethanone to obtain 2-bromo-1-(5-methyl-1-phenyl-1,2,3-triazol-4-yl)ethanone.

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Funding

This study was performed under financial support by the Ministry of Science and Higher Education of the Russian Federation (project no. 4.5183.2017/BCh) in the framework of the base part of state assignment in the sphere of research activity.

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  1. Irkutsk State University, 664003, Irkutsk, Russia

    T. V. Golobokova, A. G. Proidakov & V. N. Kizhnyaev

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  1. T. V. Golobokova
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Correspondence to T. V. Golobokova.

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Golobokova, T.V., Proidakov, A.G. & Kizhnyaev, V.N. Selective Synthesis of Functionally Substituted 1,2,3-Triazoles. Russ J Org Chem 56, 446–453 (2020). https://doi.org/10.1134/S1070428020030136

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