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Synthesis of New Thieno[2,3-b]pyridine Derivatives Based on Fused Thiophenes

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Abstract

Conditions for the Gewald synthesis of 2-amino-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyrans from 2,2-dimethyltetrahydropyran-4-ones have been optimized, and the yields have been improved. A procedure has been developed for the synthesis of new pyrano[4′,3′:4,5]thieno[2,3-b]pyridines by the Thorpe–Ziegler reaction of thieno[2,3-c]pyrans. Anticonvulsant activity of the synthesized compounds was studied.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    E. G. Paronikyan, A. S. Harutyunyan & R. G. Paronikyan

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  1. E. G. Paronikyan
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  2. A. S. Harutyunyan
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  3. R. G. Paronikyan
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Correspondence to A. S. Harutyunyan.

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Paronikyan, E.G., Harutyunyan, A.S. & Paronikyan, R.G. Synthesis of New Thieno[2,3-b]pyridine Derivatives Based on Fused Thiophenes. Russ J Org Chem 56, 422–428 (2020). https://doi.org/10.1134/S1070428020030094

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