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A Facile Approach to the Synthesis of Benzothiazoles from N-Protected Amino Acids

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Abstract

–A simple trituration method for the synthesis of 2-substituted benzothiazoles derived from N-protected amino acids and 2-aminothiophenol using molecular iodine as a mild Lewis acid catalyst has been proposed. The reaction occurs in one step for 20–25 min in solve-free conditions and provides the target products in excellent yields.

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Authors and Affiliations

  1. Department of Chemistry, School of Natural Sciences, National University of Sciences and Technology, 44000, Islamabad, Pakistan

    M. Arfan & A. Tahira

  2. Department of Pharmacy, COMSATS University, Abbottabad Campus, 22010, Abbottabad, Pakistan

    A. Mannan

  3. Department of Chemistry, COMSATS University, Islamabad Campus, 44000, Islamabad, Pakistan

    T. Fatima

Authors
  1. M. Arfan
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  2. A. Tahira
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  3. A. Mannan
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Correspondence to M. Arfan.

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Arfan, M., Tahira, A., Mannan, A. et al. A Facile Approach to the Synthesis of Benzothiazoles from N-Protected Amino Acids. Russ J Org Chem 56, 292–297 (2020). https://doi.org/10.1134/S1070428020020190

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  • DOI: https://doi.org/10.1134/S1070428020020190

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