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Synthesis and Biological Activity of Sulfamidoand Alkoxycarbonyl-substituted Nicotinic Acid Esters

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Abstract

Esterification of nicotinic acid and the reaction products of chloramine-B with allyl chloride and acrylonitrile was studied. Under the influence of the electron-acceptor sulfonamido group, the cyano group in 3-cyano-2-(benzenesulfonamido)propyl pyridine-3-carboxylate undergoes facile heterocyclization with polarophiles to form pyrrole and pyridine derivatives. Antimicrobial activity assessment of the synthesized esters showed their high efficiency

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Authors and Affiliations

  1. Quliyev Institute of Additive Chemistry, National Academy of Sciences of Azerbaijan, 1143, Baku, Azerbaijan

    A. A. Makhmudova

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  1. A. A. Makhmudova
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Correspondence to A. A. Makhmudova.

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Makhmudova, A.A. Synthesis and Biological Activity of Sulfamidoand Alkoxycarbonyl-substituted Nicotinic Acid Esters. Russ J Org Chem 56, 246–250 (2020). https://doi.org/10.1134/S1070428020020104

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  • DOI: https://doi.org/10.1134/S1070428020020104

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