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Polynuclear Aromatic Amines as N-Nucleophiles in the ipso-Substitution of the Cyano Group in 1,2,4-Triazines

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Abstract

The possibility of use of polynuclear aromatic amines as N-nucleophiles in the ipso-substitution of the 5-cyano group in 1,2,4-triazines has been studied. The influence of the structure of the aromatic amine on the result of the reaction has been demonstrated. With 3-aminobiphenyls the corresponding 5-amino-N-(biphenyl-3-yl)-1,2,4-triaizines have been obtained with yields of up to 88%.

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Funding

The work was financially supported by the Russian Science Foundation (project no. 19-73-10144).

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B.N. Eltsyn, 620002, Yekaterinburg, Russia

    E. S. Starnovskaya, M. I. Savchuk, Ya. K. Shtaitz, D. S. Kopchuk, I. S. Kovalev, D. E. Pavlyuk, A. F. Khasanov, G. V. Zyryanov & O. N. Chupakhin

  2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620990, Yekaterinburg, Russia

    E. S. Starnovskaya, D. S. Kopchuk, I. S. Kovalev, A. F. Khasanov, G. V. Zyryanov & O. N. Chupakhin

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  1. E. S. Starnovskaya
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  2. M. I. Savchuk
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  3. Ya. K. Shtaitz
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  4. D. S. Kopchuk
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  5. I. S. Kovalev
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  6. D. E. Pavlyuk
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  7. A. F. Khasanov
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  8. G. V. Zyryanov
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  9. O. N. Chupakhin
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Correspondence to G. V. Zyryanov.

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Starnovskaya, E.S., Savchuk, M.I., Shtaitz, Y.K. et al. Polynuclear Aromatic Amines as N-Nucleophiles in the ipso-Substitution of the Cyano Group in 1,2,4-Triazines. Russ J Org Chem 56, 335–338 (2020). https://doi.org/10.1134/S1070428020010268

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