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Synthesis of C3-Modified Carbapenems

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Abstract

Reactions of 4-nitrobenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate with 2-sulfanylacetamides derived from taurine and cytisine afforded the corresponding products of AdNE substitution of the diphenoxyphosphoryl group.

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Acknowledgments

The spectral and analytical data were obtained using the facilities of the Chemistry joint center (Ufa Institute of Chemistry, Russian Academy of Sciences) and Agidel regional joint center (Ufa Federal Research Center, Russian Academy of Sciences).

Funding

This study was performed under financial support by the Russian Science Foundation (project no. 15-13-00039P).

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, Ufa, 450054, Russia

    S. A. Torosyan, Z. F. Nuriakhmetova, F. A. Gimalova & M. S. Miftakhov

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  1. S. A. Torosyan
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  2. Z. F. Nuriakhmetova
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  3. F. A. Gimalova
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  4. M. S. Miftakhov
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Corresponding author

Correspondence to M. S. Miftakhov.

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The authors declare the absence of conflict of interest.

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Russian Text © The Author(s), 2020, published in Zhurnal Organicheskoi Khimii, 2020, Vol. 56, No. 1, pp. 16–20.

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Torosyan, S.A., Nuriakhmetova, Z.F., Gimalova, F.A. et al. Synthesis of C3-Modified Carbapenems. Russ J Org Chem 56, 7–10 (2020). https://doi.org/10.1134/S1070428020010029

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  • DOI: https://doi.org/10.1134/S1070428020010029

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