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Reaction of Thioxanthylium Cation with Pharmacophoric Heterocyclic Amines

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Abstract

Reactions of thioxanthylium tetrafluoroborate with pharmacophoric heterocyclic amines, pyrimidin-2-amine, 4,6-dimethylpyrimidin-2-amine, 2-aminopyrimidine-4,6-diol, and 1,3,4-thiadiazole-2,5-diamine, gave stable products of electrophilic substitution of one hydrogen atom per amino group. The product structure was confirmed by 1H NMR and mass spectra and X-ray analysis of N-(9H-tmoxanthen-9-yl)pyrimidin-2-amine.

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Funding

This study was performed under financial support by the Russian Foundation for Basic Research (project no. 19-0300888).

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Authors and Affiliations

  1. Pryanishnikov Perm State Agro-Technological University, Perm, 614990, Russia

    L. P. Yunnikova & V. V. Esenbaeva

  2. Ivanovo State University of Chemistry and Technology, Ivanovo, 153000, Russia

    E. A. Danilova & M. K. Islyaikin

Authors
  1. L. P. Yunnikova
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  2. V. V. Esenbaeva
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  3. E. A. Danilova
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  4. M. K. Islyaikin
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Corresponding author

Correspondence to L. P. Yunnikova.

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Conflict of Interests

The authors declare the absence of conflict of interests.

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 12, pp. 1953–1956.

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Yunnikova, L.P., Esenbaeva, V.V., Danilova, E.A. et al. Reaction of Thioxanthylium Cation with Pharmacophoric Heterocyclic Amines. Russ J Org Chem 55, 1985–1987 (2019). https://doi.org/10.1134/S1070428019120327

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  • DOI: https://doi.org/10.1134/S1070428019120327

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