Abstract
The title compounds were synthesized in good yields by one-pot four-component condensation of phthaloyl dichloride, ethyl cyanoacetohydrazide, malononitrile, and substituted benzaldehydes in boiling ethanol for 1–2 h. The reaction involves in situ generation of hydrogen chloride in the first step, which catalyzes further addition, dehydration, and cyclization steps. The procedure is advantageous due to easy workup, short reaction times, good yields, the use of ethanol as a green solvent, and no external catalyst is needed.
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Acknowledgments
The authors are thankful to GVK Biosciences Private Limited (IDA Nacharam, Hyderabad, Telangana, India) and Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology & Research University (Vadlamudi, Guntur, Andhra Pradesh, India) for providing facilities to perform this study.
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Karunakar, P., Kumar, C.N.S.S.P. Self-Catalyzed One-Pot Four-Component Green Synthesis of 2-Amino-6-[1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl]-4-phenyl-4H-pyran-3,5-dicarbonitriles. Russ J Org Chem 55, 1936–1939 (2019). https://doi.org/10.1134/S1070428019120212
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DOI: https://doi.org/10.1134/S1070428019120212