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Synthesis of New Guanidine-Containing Amphiphiles and Their Pyrene Analog for Liposomal Delivery Systems and Visualization in Target Cells

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Abstract

New cationic amphiphiles with a guanidine head group have been synthesized starting from lipoamino acids with the goal of creating drug and genetic material delivery systems. Their analog containing a pyrene fragment has also been obtained as a potential agent for visualization of liposome transport in various cells.

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Funding

This study was performed under financial support by the Russian Foundation for Basic Research (project no. 17-04-01141-a).

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Authors and Affiliations

  1. Lomonosov Moscow Institute of Fine Chemical Technology, MIREA-Russian Technological University, Moscow, 119454, Russia

    A. A. Loseva, U. A. Budanova & Yu. L. Sebyakin

Authors
  1. A. A. Loseva
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  2. U. A. Budanova
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  3. Yu. L. Sebyakin
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Corresponding author

Correspondence to U. A. Budanova.

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Conflict of Interests

The authors declare the absence of conflict of interests.

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 12, pp. 1827–1833.

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Loseva, A.A., Budanova, U.A. & Sebyakin, Y.L. Synthesis of New Guanidine-Containing Amphiphiles and Their Pyrene Analog for Liposomal Delivery Systems and Visualization in Target Cells. Russ J Org Chem 55, 1826–1831 (2019). https://doi.org/10.1134/S1070428019120030

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  • DOI: https://doi.org/10.1134/S1070428019120030

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