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Synthesis of Novel 2-(N-Substituted)imino-2,5-dihydrofuran-3-carboxamides Containing a Thiourea Residue and an Oxothiazolidinylidene Ring

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Abstract

Novel derivatives of 2-imino-2,5-dihydrofuran-3-carboxamides containing a thiourea residue have been synthesized by the reaction of 2-imino-2,5-dihydrofuran-3-carboxamides with thiosemicarbazide in glacial acetic acid. The synthesized N-substituted iminodihydrofurans have been condensed with ethyl chloroacetate to obtain novel derivatives of iminodihydrofurans containing an oxothiazolidinylidene ring. These methods open up new synthetic approaches to previously unknown systems containing iminodihydrofuran, thiourea and oxothiazolidinylidene fragments.

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Authors and Affiliations

  1. Yerevan State University, ul. Aleka Manukyana 1, Yerevan, 10025, Armenia

    L. V. Karapetyan & G. G. Tokmajyan

  2. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    G. M. Makaryan

Authors
  1. L. V. Karapetyan
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  2. G. G. Tokmajyan
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  3. G. M. Makaryan
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Corresponding author

Correspondence to L. V. Karapetyan.

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The authors declare no conflict of interest.

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Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 11, pp. 1796–1799.

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Karapetyan, L.V., Tokmajyan, G.G. & Makaryan, G.M. Synthesis of Novel 2-(N-Substituted)imino-2,5-dihydrofuran-3-carboxamides Containing a Thiourea Residue and an Oxothiazolidinylidene Ring. Russ J Org Chem 55, 1806–1808 (2019). https://doi.org/10.1134/S1070428019110265

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  • DOI: https://doi.org/10.1134/S1070428019110265

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