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Efficient Synthesis of 4-Phenyl-4H-pyran Derivatives via a DIPEA-catalyzed One-Pot Three-Component Reaction

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Abstract

A novel one-pot approach has been developed for a high-yield synthesis of 4-phenyl-4H-pyran derivatives by the three-component condensation of dimethyl 3-oxopentanedioate or 3-oxo-3-arylpropanoic acid esters, aldehydes, with malononitrile in the presence of a DIPEA catalyst in ethanol at room temperature. The significant features of the present strategy include efficiency, high yield, inexpensive catalyst, mild reaction conditions, and simple purification procedure.

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Funding

This study was financially supported by the Shenyang Science & Technology project (project no. 18-013-0-03) and Natural Science Funds for Young Scholar of Liaoning University (project no. LDQN201436).

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Correspondence to Ye Chen or Ju Liu.

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Li, J., Li, J., Hu, Sy. et al. Efficient Synthesis of 4-Phenyl-4H-pyran Derivatives via a DIPEA-catalyzed One-Pot Three-Component Reaction. Russ J Org Chem 55, 1791–1799 (2019). https://doi.org/10.1134/S107042801911023X

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  • DOI: https://doi.org/10.1134/S107042801911023X

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