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Easy Strategy for the Synthesis of New 5,6-Dihydro-[1,2,4]triazolo[4,3-a][1,3,5]triazine Derivatives

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Abstract

New substituted 5,6-dihydro[1,2,4]triazolo[4,3-a][1,3,5]triazines were synthesized by cyclocondensation of N-alkyl(aryl)-N′-(4H-1,2,4-triazol-3-yl)ethan- and -propanimidamides with benzaldehyde or ethyl methyl ketone in the presence of p-toluenesulfonic acid in 1,4-dioxane under reflux. The reaction tolerated a broad substrate scope and provided good yields (43–64%). The structure of the newly synthesized compounds was confirmed by elemental analyses and IR, 1H and 13C NMR, and mass spectra.

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Authors and Affiliations

  1. Laboratory of Functional Physiology and Valuation of Bio-resources (UR17ES27), Higher Institute of Biotechnology of Béja, University of Jendouba, Béja, Tunisia

    A. Hajri & L. Marzouki

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  1. A. Hajri
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  2. L. Marzouki
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Correspondence to A. Hajri.

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Hajri, A., Marzouki, L. Easy Strategy for the Synthesis of New 5,6-Dihydro-[1,2,4]triazolo[4,3-a][1,3,5]triazine Derivatives. Russ J Org Chem 55, 1394–1398 (2019). https://doi.org/10.1134/S1070428019090203

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  • DOI: https://doi.org/10.1134/S1070428019090203

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