Abstract
The reaction of 2-methyl-4H-3,1-benzoxazin-4-one and its 6-iodo derivatives with a number of amines in polyphosphoric acid afforded 3- and 3,6-substituted 2-methylquinazolin-4(3H)-ones. The latter reacted with aromatic and heterocyclic aldehydes under solvent-free conditions to give 2-[(E)-2-arylethenyl]-quinazolin-4(3H)-ones. The structure of the synthesized compounds was confirmed by two-dimensional 1H–1H NOESY data and X-ray analysis.
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This study was performed at the Russian Armenian University under financial support by the Ministry of Science and Higher Education of the Russian Federation.
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Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 9, pp. 1453–1460.
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Harutyunyan, A.A., Gukasyan, G.T., Panosyan, H.A. et al. Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure. Russ J Org Chem 55, 1363–1369 (2019). https://doi.org/10.1134/S107042801909015X
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DOI: https://doi.org/10.1134/S107042801909015X