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A Convenient Synthesis of [1,2,3]Triazolo[1,5-a]quinoline

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Abstract

The reaction of methyl 2-azido-5-bromobenzoate with ethyl 4-(ethylsulfanyl)-3-oxobutanoate was used to synthesize ethyl 1-[4-bromo-2-(methoxycarbonyl)phenyl)]-5-(ethylsulfanylmethyl)-1H-1,2,3-triazole-4-carboxylate. The subsequent oxidation of the sulfide sulfur with H2O2 and treatment with sodium hydride gave ethyl 7-bromo-4-(ethylsulfonyl)-5-hydroxy[1,2,3]triazolo[1,5-a]quinoline-3-carboxylate.

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Authors and Affiliations

  1. Ivan Franko National University of Lviv, ul. Kyryla i Mefodiya 6, Lviv, 79005, Ukraine

    N. T. Pokhodylo & M. D. Obushak

Authors
  1. N. T. Pokhodylo
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  2. M. D. Obushak
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Correspondence to M. D. Obushak.

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Conflict of Interest

The authors declare no conflict of interest.

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 8, pp. 1300–1303.

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Pokhodylo, N.T., Obushak, M.D. A Convenient Synthesis of [1,2,3]Triazolo[1,5-a]quinoline. Russ J Org Chem 55, 1241–1243 (2019). https://doi.org/10.1134/S107042801908027X

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  • DOI: https://doi.org/10.1134/S107042801908027X

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