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Synthesis of Symmetrical Bisisoquinolinediones

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Abstract

A method of synthesis of 1,1′-(alkanediyl)bis{3-cyano-4-[4,5,5-trimethyl-2-oxo-5H-furan-3-yl]-pyridin-2(1H)-ones} from the corresponding lactones is developed. The synthesized compounds undergo intramolecular cyclization to form symmetrical 7,7′-(alkanediyl)bis{5-amino-3,3-dimethylfuro[3,4-f]isoquinoline-1,6(3H,7H)-diones}.

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Acknowledgments

The work was financially supported by the Ministry of Education and Science of the Republic of Armenia (grant no. 18T-2E151).

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Authors and Affiliations

  1. Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    R. M. Hakobyan

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  1. R. M. Hakobyan
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Correspondence to R. M. Hakobyan.

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The authors declare no conflict of interest.

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 8, pp. 1296–1299.

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Hakobyan, R.M. Synthesis of Symmetrical Bisisoquinolinediones. Russ J Org Chem 55, 1238–1240 (2019). https://doi.org/10.1134/S1070428019080268

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  • DOI: https://doi.org/10.1134/S1070428019080268

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