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Synthesis and Anticancer Activity of Certain Selenophene Derivatives

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Abstract

Selenopheno[2,3-d]pyrimidine- and selenopheno[2,3-d][1,2,3]triazine-containing compounds were synthesized starting from 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]selenophene-3-carbonitrile. In vitro anticancer activity of the newly synthesized compounds was tested using 60 different human cancer cell lines.

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Authors and Affiliations

  1. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt

    M. E. Adly, E. M. Gedawy, A. A. El-Malah & F. A. El-Telbany

  2. Pharmaceutical Chemistry Department, Faculty of Pharmacy and Pharmaceutical Industries, Badr University (BUC), Cairo, 11829, Egypt

    E. M. Gedawy

  3. Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Technology, Heliopolis University, Cairo, 11785, Egypt

    A. A. El-Malah

Authors
  1. M. E. Adly
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  2. E. M. Gedawy
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  3. A. A. El-Malah
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  4. F. A. El-Telbany
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Correspondence to M. E. Adly.

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The authors declare no conflict of interest.

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 8, pp. 1307.

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Adly, M.E., Gedawy, E.M., El-Malah, A.A. et al. Synthesis and Anticancer Activity of Certain Selenophene Derivatives. Russ J Org Chem 55, 1189–1196 (2019). https://doi.org/10.1134/S1070428019080189

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  • DOI: https://doi.org/10.1134/S1070428019080189

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