Abstract
New selenoxopyrimidines were synthesized by one-pot multicomponent reaction of ethyl aceto-acetate, with aromatic aldehydes and selenourea in acidic medium. The synthesized compounds were shown to possess a broad spectrum of antimicrobial activity in vitro. The in vitro anticancer activity of some compounds was studied against MCF-7 human breast cell line using MTT assay. All tested compounds have shown a significant anticancer activity, and 4-phenyl-substituted derivative was found to be most effective anticancer agent (cell viability 50% against 41% for Paclitaxel). The structure-activity relationship (SAR) analysis showed that electron-donating substituents favor anticancer and antibacterial activity and that electron-withdrawing substituents favor antifungal activity.
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The authors are grateful to UGC, New Delhi, for providing financial assistance and to Department of Chemistry, Punjabi University, Patiala, for providing all the necessary facilities for research and antimicrobial evaluations.
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Samdhian, V., Bhatia, S.K. & Kaur, B. Cell-Viability Analysis Against MCF-7 Human Breast Cell Line and Antimicrobial Evaluation of Newly Synthesized Selenoxopyrimidines. Russ J Org Chem 55, 1041–1046 (2019). https://doi.org/10.1134/S1070428019070212
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DOI: https://doi.org/10.1134/S1070428019070212