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Green Synthetic Approach and Antimicrobial Evaluation for Some Novel Pyridyl Benzoate Derivatives

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Abstract

Two series of substituted pyridyl 4-chlorobenzoates have been synthesized by microwave-assisted condensation of the corresponding 2-oxo-1,2-dihydropyridine-3-carbonitriles with 4-chlorobenzoyl chloride under solvent-free conditions. Alternatively, some compounds have also been prepared by conventional heating in methylene chloride in the presence of triethylamine. The structure of the synthesized compounds has been confirmed by spectral data (FTIR, 1D and 2D NMR). The new pyridyl benzoates were evaluated for antibacterial activity against gram-negative and gram-positive bacteria. The activity of 3-cyano-5-[(4-hydroxyphenyl)diazenyl]-4-methyl-6-phenylpyridin-2-yl 4-chlorobenzoate against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) was comparable to that of amikacin used as standard antibiotic.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia

    H. A. Eldeab

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  1. H. A. Eldeab
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Correspondence to H. A. Eldeab.

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Funding

This work was financially supported by research grant from Taif University, Kingdom of Saudi Arabia (grant no. 1-438-5953).

Conflict of Interests

The author declares the absence of conflict of interests.

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Eldeab, H.A. Green Synthetic Approach and Antimicrobial Evaluation for Some Novel Pyridyl Benzoate Derivatives. Russ J Org Chem 55, 1034–1040 (2019). https://doi.org/10.1134/S1070428019070200

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  • DOI: https://doi.org/10.1134/S1070428019070200

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