Abstract
An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.
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The authors thank the Laboratory of Organic Functional Molecules, the Sino-French Institute of ECNU, for supports.
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Zhu, H.T., Qin, L.Y., Liu, T. et al. A Convenient Synthesis of N2-Alkylated Guanines. Russ J Org Chem 55, 874–878 (2019). https://doi.org/10.1134/S1070428019060198
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DOI: https://doi.org/10.1134/S1070428019060198