Multicomponent Synthesis of Thiazole, Selenazole, Pyrane, and Pyridine Derivatives, Initiated by the Knoevenagel Reaction

Abstract

(2E,2′E)-3,3′-(Propane-1,3-diyl)bis[oxy(4,1-phenylene)]bis[2-(4-aryl-1,3-thiazol-2-yl)acrylonitriles] and functionally substituted pyridines and fused pyrans containing a 3-[1,3-thi(selen)azol-2-yl]-substituent were synthesized by multicomponent condensations initiated by the Knoevenagel reaction. The structures of 2-amino-5-oxo-4-(1-phenylethyl)-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile and 2-amino-7-hexyloxy-4-cyclohexyl-4H-chromene-3-carborutrile were studied by X-ray diffraction analysis.

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Correspondence to V. G. Nenaidenko.

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Russian Text © I.V. Dyachenko, V.D. Dyachenko, P.V. Dorovatovskii, V.N. Khrustalev, V.G. Nenaidenko, 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 2, pp. 266–278.

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Dyachenko, I.V., Dyachenko, V.D., Dorovatovskii, P.V. et al. Multicomponent Synthesis of Thiazole, Selenazole, Pyrane, and Pyridine Derivatives, Initiated by the Knoevenagel Reaction. Russ J Org Chem 55, 215–226 (2019). https://doi.org/10.1134/S1070428019020131

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Keywords

  • thiazole
  • selenazole
  • pyran
  • pyridine
  • Knoevenagel reaction
  • X-ray structural analysis