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Synthesis of 2-Cyanoethoxy and 2-(1H-Tetrazol-5-yl)ethoxy Derivatives of Glycyrrhetic Acid Methyl Ester

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Abstract

Cyanoethylation of natural glycyrrhetic acid methyl ester gave the corresponding 3β-O-(2-cyanoethyl) derivative which was treated with sodium azide to obtain a novel tetrazolyl derivative of biologically active triterpenoid, methyl 3β-[2-(1H-tetrazol-5-yl)ethoxy]-11-oxoolean-12-en-30-oate.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia

    A. D. Zorina, V. L. Polozova, S. A. Marchenko, S. I. Selivanov & R. E. Trifonov

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  1. A. D. Zorina
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  2. V. L. Polozova
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  3. S. A. Marchenko
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  4. S. I. Selivanov
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  5. R. E. Trifonov
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Corresponding author

Correspondence to R. E. Trifonov.

Additional information

Original Russian Text © A.D. Zorina, V.L. Polozova, S.A. Marchenko, S.I. Selivanov, R.E. Trifonov, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 12, pp. 1853–1855.

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Zorina, A.D., Polozova, V.L., Marchenko, S.A. et al. Synthesis of 2-Cyanoethoxy and 2-(1H-Tetrazol-5-yl)ethoxy Derivatives of Glycyrrhetic Acid Methyl Ester. Russ J Org Chem 54, 1868–1870 (2018). https://doi.org/10.1134/S1070428018120278

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  • DOI: https://doi.org/10.1134/S1070428018120278

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