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Reaction of 2-(2-Oxo-1,2-dihydro-3H-pyrrol-3-ylidene)- malononitriles with C-Nucleophiles. Synthesis of New Spiro-Fused Pyrrole Derivatives

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Abstract

Base-catalyzed nucleophilic addition of carbon nucleophiles to the exocyclic double bond of 2-(5-aryl-4-methyl-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene)malononitriles afforded spiro-fused pyrrole derivatives, 7-amino-3-aryl-4-methyl-1-oxo-8-oxa-2-azaspiro[4.5]deca-3,6,9-triene-6-carbonitriles. The products can be regarded as rare structural analogs of biologically active spirans based on isatin.

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Authors and Affiliations

  1. I.N. Ul’yanov Chuvash State University, Moskovskii pr. 15, Cheboksary, 428015, Russia

    A. G. Milovidova, M. Yu. Belikov, M. Yu. Ievlev, O. V. Ershov & O. E. Nasakin

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  1. A. G. Milovidova
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  2. M. Yu. Belikov
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  3. M. Yu. Ievlev
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  4. O. V. Ershov
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  5. O. E. Nasakin
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Correspondence to M. Yu. Belikov.

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Original Russian Text © A.G. Milovidova, M.Yu. Belikov, M.Yu. Ievlev, O.V. Ershov, O.E. Nasakin, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 12, pp. 1776–1779.

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Milovidova, A.G., Belikov, M.Y., Ievlev, M.Y. et al. Reaction of 2-(2-Oxo-1,2-dihydro-3H-pyrrol-3-ylidene)- malononitriles with C-Nucleophiles. Synthesis of New Spiro-Fused Pyrrole Derivatives. Russ J Org Chem 54, 1790–1793 (2018). https://doi.org/10.1134/S1070428018120084

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  • DOI: https://doi.org/10.1134/S1070428018120084

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