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Synthesis and Properties of N-[R-Adamantan-1(2)-yl]-N′-(2-fluorophenyl)ureas—Target-Oriented Soluble Epoxide Hydrolase Inhibitors

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Abstract

2-Fluorophenyl isocyanate reacted with adamantan-1(2)-amines and their homologs in DMF to give 31–92% of the corresponding N,N′-disubstituted ureas that are target-oriented human soluble epoxide hydrolase (sEH) inhibitors. Introduction of a fluorine atom increases the sEH inhibitory activity by a factor of 4.5.

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Authors and Affiliations

  1. Volzhskii Polytechnic Institute (Branch), Volgograd State Technical University, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121, Russia

    V. V. Burmistrov & G. M. Butov

  2. Volgograd State Technical University, pr. Lenina 28, Volgograd, 400005, Russia

    G. M. Butov

Authors
  1. V. V. Burmistrov
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  2. G. M. Butov
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Correspondence to G. M. Butov.

Additional information

Original Russian Text © V.V. Burmistrov, G.M. Butov, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 9, pp. 1296–1301.

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Burmistrov, V.V., Butov, G.M. Synthesis and Properties of N-[R-Adamantan-1(2)-yl]-N′-(2-fluorophenyl)ureas—Target-Oriented Soluble Epoxide Hydrolase Inhibitors. Russ J Org Chem 54, 1307–1312 (2018). https://doi.org/10.1134/S1070428018090063

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  • DOI: https://doi.org/10.1134/S1070428018090063

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