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New Synthesis of Pyrano[4,3-d]pyrazolo[3,4-b]pyridines

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Abstract

A new efficient method has been developed for the synthesis of highly biologically active pyrano-[4,3-d]pyrazolo[3,4-b]pyridines on the basis of Smiles rearrangement of ethyl [(8-alkyl(aryl)-5-cyano-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-6-yl)oxy]acetates. Intermediate acetohydrazides have also been isolated. The proposed procedure is advantageous due to the possibility of avoiding experimentally difficult chlorination stage.

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Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, Erevan, 0014, Armenia

    S. N. Sirakanyan, E. K. Hakobyan & A. A. Hovakimyan

Authors
  1. S. N. Sirakanyan
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  2. E. K. Hakobyan
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  3. A. A. Hovakimyan
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Correspondence to S. N. Sirakanyan.

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Original Russian Text © S.N. Sirakanyan, E.K. Hakobyan, A.A. Hovakimyan, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 6, pp. 924–927.

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Sirakanyan, S.N., Hakobyan, E.K. & Hovakimyan, A.A. New Synthesis of Pyrano[4,3-d]pyrazolo[3,4-b]pyridines. Russ J Org Chem 54, 929–932 (2018). https://doi.org/10.1134/S1070428018060167

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  • DOI: https://doi.org/10.1134/S1070428018060167

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