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Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles

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Abstract

Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia

    D. V. Seliverstova, V. V. Suslonov & R. E. Trifonov

  2. Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, ul. Mira 14, St. Petersburg, 197101, Russia

    V. V. Zarubaev

Authors
  1. D. V. Seliverstova
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  2. V. V. Suslonov
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  3. V. V. Zarubaev
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  4. R. E. Trifonov
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Corresponding author

Correspondence to R. E. Trifonov.

Additional information

Original Russian Text © D.V. Seliverstova, V.V. Suslonov, V.V. Zarubaev, R.E. Trifonov, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 4, pp. 630–635.

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Seliverstova, D.V., Suslonov, V.V., Zarubaev, V.V. et al. Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles. Russ J Org Chem 54, 633–638 (2018). https://doi.org/10.1134/S107042801804019X

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  • DOI: https://doi.org/10.1134/S107042801804019X

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