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Three-Component Spiro Heterocyclization of Pyrrolediones with Malononitrile and Cyclic Enols

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Abstract

Ethyl 4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylates reacted with malononitrile and five-membered cyclic enols, indan-1,3-dione and cyclopentane-1,3-dione to give 1-substituted ethyl 2-amino-3- cyano-2′,5-dioxo-5′-phenyl-1′,2′-dihydro-5H-spiro[indeno[1,2-b]pyran-4,3′-pyrrole]-4′-carboxylates and ethyl 2-amino-3-cyano-2′,5-dioxo-5′-phenyl-1′,2′,6,7-tetrahydro-5H-spiro[cyclopenta[b]pyran-4,3′-pyrrole]-4′-carboxylates, respectively.

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Correspondence to A. N. Maslivets.

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Original Russian Text © T.V. Sal’nikova, M.V. Dmitriev, E.V. Bushmeleva, P.S. Silaichev, A.N. Maslivets, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 4, pp. 564–567.

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Sal’nikova, T.V., Dmitriev, M.V., Bushmeleva, E.V. et al. Three-Component Spiro Heterocyclization of Pyrrolediones with Malononitrile and Cyclic Enols. Russ J Org Chem 54, 564–567 (2018). https://doi.org/10.1134/S1070428018040073

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  • DOI: https://doi.org/10.1134/S1070428018040073

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