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Fused Pyrimidine Systems: XVII. Imidazo- and Pyrimidopyrido[3,2-d]pyrimidin-4(3H)-ones

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Abstract

2-(Allylamino)pyrido[3,2-d]pyrimidin-4(3H)-one was converted to linearly fused dihydroimidazo- [1,2-a]pyrido[3,2-d]pyrimidine on heating in polyphosphoric acid, whereas its reactions with molecular iodine and chlorosulfanylarenes afforded mainly angularly fused analogs. 2-(Cinnamylamino)pyrido[3,2-d]pyrimidin- 4(3H)-one reacted with polyphosphoric acid and chlorosulfanylarenes to give linear pyrido[3,2-d]pyrimido-[1,2-a]pyrimidinones, and its iodocyclization led to the formation of angularly fused derivative.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02094, Ukraine

    I. V. Dyachenko, R. I. Vas’kevich & M. V. Vovk

  2. “Igor Sikorsky Kyiv Polytechnic Institute” National Technical University of Ukraine, Pr. Peremohy 37, Kiev, 03056, Ukraine

    A. I. Vas’kevich

  3. “Enamin” Scientific Industrial Association, Kiev, Ukraine

    V. V. Polovinko

Authors
  1. I. V. Dyachenko
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  2. R. I. Vas’kevich
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  3. A. I. Vas’kevich
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  4. V. V. Polovinko
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  5. M. V. Vovk
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Correspondence to I. V. Dyachenko.

Additional information

Original Russian Text © I.V. Dyachenko, R.I. Vas’kevich, A.I. Vas’kevich, V.V. Polovinko, M.V. Vovk, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 3, pp. 431–438.

For communication XVI, see [1].

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Dyachenko, I.V., Vas’kevich, R.I., Vas’kevich, A.I. et al. Fused Pyrimidine Systems: XVII. Imidazo- and Pyrimidopyrido[3,2-d]pyrimidin-4(3H)-ones. Russ J Org Chem 54, 436–443 (2018). https://doi.org/10.1134/S1070428018030119

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  • DOI: https://doi.org/10.1134/S1070428018030119

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