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Synthesis and antihypoxic activity of new aminothiadiazolylbenzodioxane derivatives

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Abstract

Intramolecular cyclization of 2-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)hydrazine-1-carbothioamide by the action of concentrated sulfuric acid gave 5-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3,4-thiadiazol-2-amine which was acylated with acid chlorides, and the resulting amides were reduced with LiAlH4 to afford the corresponding N-substituted 5-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3,4-thiadiazol-2-amine derivatives.

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Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    S. O. Vartanyan, A. S. Avakyan, A. B. Sargsyan, M. O. Kerobyan, S. A. Arutyunyan & T. G. Gukasyan

Authors
  1. S. O. Vartanyan
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  2. A. S. Avakyan
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  3. A. B. Sargsyan
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  4. M. O. Kerobyan
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  5. S. A. Arutyunyan
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  6. T. G. Gukasyan
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Corresponding author

Correspondence to A. S. Avakyan.

Additional information

Original Russian Text © S.O. Vartanyan, A.S. Avakyan, A.B. Sargsyan, M.O. Kerobyan, S.A. Arutyunyan, T.G. Gukasyan, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 12, pp. 1869–1871.

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Vartanyan, S.O., Avakyan, A.S., Sargsyan, A.B. et al. Synthesis and antihypoxic activity of new aminothiadiazolylbenzodioxane derivatives. Russ J Org Chem 53, 1905–1908 (2017). https://doi.org/10.1134/S1070428017120259

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  • DOI: https://doi.org/10.1134/S1070428017120259

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