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Synthesis of 2-(3,4,5-trimethoxybenzoyl)-4(5)-phenyl-1H-imidazole

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Abstract

The condensation of (2E)-N-hydroxy-2-hydroxyimino-2-phenylethanamine with 3,4,5-trimethoxyphenylglyoxal afforded (1-hydroxy-5-phenyl-1H-imidazol-2-yl)phenylmethanone which reacted with trimethyl phosphite or chloroacetone to give 2-(3,4,5-trimethoxybenzoyl)-4(5)-phenyl-1H-imidazole.

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Authors and Affiliations

  1. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090, Russia

    E. B. Nikolaenkova, I. A. Os’kina & A. Ya. Tikhonov

Authors
  1. E. B. Nikolaenkova
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  2. I. A. Os’kina
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  3. A. Ya. Tikhonov
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Correspondence to I. A. Os’kina.

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Original Russian Text © E.B. Nikolaenkova, I.A. Os’kina, A.Ya. Tikhonov, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 12, pp. 1851–1853.

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Nikolaenkova, E.B., Os’kina, I.A. & Tikhonov, A.Y. Synthesis of 2-(3,4,5-trimethoxybenzoyl)-4(5)-phenyl-1H-imidazole. Russ J Org Chem 53, 1887–1889 (2017). https://doi.org/10.1134/S1070428017120193

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  • DOI: https://doi.org/10.1134/S1070428017120193

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