N-acylimino-substituted 2-oxa-7-azaspiro[4.4]nona-3,6,8-trienes in the synthesis of 3-(1H-1,2,4-triazol-3-yl)-3H-pyrrole-4-carbonitriles


Reaction with phenylhydrazine of 3Н-pyrroles spirobound to a furan ring, N-acylimino-substituted 2-oxa-7-azaspiro[4.4]nona-3,6,8-trienes, occurs with a diasteroselective formation of previously unknown derivatives of 1,2,4-triazole: 5-amino-3-(5-alkyl-1-phenyl-1H-1,2,4-triazol-3-yl)-2-morpholin-4-yl-3H-pyrrole-4-carbonitriles.

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Correspondence to M. Yu. Belikov.

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Original Russian Text © M.Yu. Belikov, I.V. Belikova, O.V. Ershov, S.V. Fedoseev, V.A. Tafeenko, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 11, pp. 1659–1663.

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Belikov, M.Y., Belikova, I.V., Ershov, O.V. et al. N-acylimino-substituted 2-oxa-7-azaspiro[4.4]nona-3,6,8-trienes in the synthesis of 3-(1H-1,2,4-triazol-3-yl)-3H-pyrrole-4-carbonitriles. Russ J Org Chem 53, 1696–1700 (2017). https://doi.org/10.1134/S107042801711015X

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