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Synthesis of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids

Abstract

Basing on natural amino acid L-cysteine, commercially available aliphatic aldehydes, 2-acetylsulfanylbenzoyl chloride and 2,2′-disulfandiyldibenzoyl dichloride a synthesis was developed of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids, potential antihypertensive compounds, inhibitors of angiotensin transforming enzyme.

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Correspondence to А. Yu. Ershov.

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Original Russian Text © A.Yu. Ershov, I.V. Lagoda, D.G. Nasledov, M.Yu. Vasil’eva, L.Yu. Kuleshova, L.V. Pavlova, A.V. Yakimanskii, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 11, pp. 1646–1650.

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Ershov, А.Y., Lagoda, I.V., Nasledov, D.G. et al. Synthesis of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids. Russ J Org Chem 53, 1682–1686 (2017). https://doi.org/10.1134/S1070428017110124

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  • DOI: https://doi.org/10.1134/S1070428017110124