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Unusual behavior of 3,5-dimethylpyrazole in the aza-Michael reaction with crotonaldehyde in aqueous medium

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Abstract

The aza-Michael reaction of 3,5-dimethylpyrazole with crotonaldehyde in water involved addition of two aldehyde molecules with formation of 2-[2-(3,5-dimethyl-1H-pyrazol-1-yl)propyl]-6-methyl-1,3-dioxan-4-ol. The latter exists in solution as equilibrium mixture with monocyclic 3-{[3-(3,5-dimethyl-1H-pyrazol-1-yl)-1-hydroxybutyl]oxy}butanal.

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References

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Authors and Affiliations

  1. Institute of Organic Chenistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of Armenia, Azatutyan av. 26, Yerevan, 0014, Armenia

    H. N. Khachatryan, S. S. Hayotsyan & K. S. Badalyan

  2. Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of Armenia, Azatutyan av. 26, Yerevan, 0014, Armenia

    A. G. Aivazyan

  3. Russian–Armenian (Slavic) University, Hovsep Emin st. 125, Yerevan, 0051, Armenia

    G. G. Danagulyan & H. S. Attaryan

Authors
  1. H. N. Khachatryan
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  2. S. S. Hayotsyan
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  3. K. S. Badalyan
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  4. A. G. Aivazyan
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  5. G. G. Danagulyan
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  6. H. S. Attaryan
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Corresponding author

Correspondence to H. S. Attaryan.

Additional information

Original Russian Text © H.N. Khachatryan, S.S. Hayotsyan, K.S. Badalyan, A.G. Aivazyan, G.G. Danagulyan, H.S. Attaryan, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 10, pp. 1570–1572.

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Khachatryan, H.N., Hayotsyan, S.S., Badalyan, K.S. et al. Unusual behavior of 3,5-dimethylpyrazole in the aza-Michael reaction with crotonaldehyde in aqueous medium. Russ J Org Chem 53, 1606–1608 (2017). https://doi.org/10.1134/S1070428017100220

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  • DOI: https://doi.org/10.1134/S1070428017100220

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