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Synthesis of 5-aryl(hetaryl)-4-methyl-2-(furan-2-yl)-1H-imidazol-1-oles

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Abstract

Reaction of 2-(hydroxyamino)-1-R-propan-1-one oximes with furfural in methanol afforded the corresponding α-furylnitrones. The cyclization of α-furylnitrones in alkaline medium results in the formation of 5-aryl(hetaryl)-2-(furan-2-yl)-1H-imidazol-1-oles.

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Authors and Affiliations

  1. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavryent’eva 9, Novosibirsk, 630090, Russia

    I. A. Os’kina & А. Ya. Tikhonov

Authors
  1. I. A. Os’kina
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  2. А. Ya. Tikhonov
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Corresponding author

Correspondence to I. A. Os’kina.

Additional information

Original Russian Text © I.A. Os’kina, А.Ya. Tikhonov, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 8, pp. 1223–1226.

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Os’kina, I.A., Tikhonov, А.Y. Synthesis of 5-aryl(hetaryl)-4-methyl-2-(furan-2-yl)-1H-imidazol-1-oles. Russ J Org Chem 53, 1239–1242 (2017). https://doi.org/10.1134/S1070428017080139

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  • DOI: https://doi.org/10.1134/S1070428017080139

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