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Synthesis of methyl 4-aryl-4-oxo-2-[(4-sulfamoylphenyl)amino]but-2-enoates and their reaction with ninhydrin

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Abstract

The reaction of methyl 4-aryl-2,4-dioxobut-2-enoates with 4-aminobenzenesulfonamide in acetic acid–ethanol (1: 1) afforded methyl (2Z)-4-aryl-4-oxo-2-(4-sulfamoylanilino)but-2-enoates which reacted with ninhydrin in glacial acetic acid to give 3-aroyl-4-(4-sulfamoylanilino]-5H-spiro[furan-2,2′-indene]-1′,3′,5-triones.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, ul. Polevaya 2, Perm, 614990, Russia

    V. L. Gein & O. V. Bobrovskaya

  2. Perm State Natsional Research University, ul. Bukireva 15, Perm, 614990, Russia

    M. V. Dmitriev

Authors
  1. V. L. Gein
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  2. O. V. Bobrovskaya
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  3. M. V. Dmitriev
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Correspondence to V. L. Gein.

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Original Russian Text © V.L. Gein, O.V. Bobrovskaya, M.V. Dmitriev, 2017, published in Zhurnal Organicheskoi Khimii, 2017, Vol. 53, No. 6, pp. 881–886.

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Gein, V.L., Bobrovskaya, O.V. & Dmitriev, M.V. Synthesis of methyl 4-aryl-4-oxo-2-[(4-sulfamoylphenyl)amino]but-2-enoates and their reaction with ninhydrin. Russ J Org Chem 53, 898–903 (2017). https://doi.org/10.1134/S1070428017060148

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  • DOI: https://doi.org/10.1134/S1070428017060148

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