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Iodocyclization of 2-[allyl(methallyl)sulfanyl]-6-(trifluoromethyl)pyrimidin-4(3H)-ones

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Abstract

Iodination of 2-[allyl(methallyl)sulfanyl]-6-(trifluoromethyl)pyrimidin-4(3H)-ones was accompanied by cyclization to 2,3-dihydro[1,3]thiazolo[3,2-a]pyrimidin-4-ium triiodides. 3-(Iodomethyl)-3-methyl- 7-oxo-5-(trifluoromethyl)-2,3-dihydro[1,3]thiazolo[3,2-a]pyrimidin-4-ium triiodide was reduced with sodium iodide to 3,3-dimethyl-7-oxo-5-(trifluoromethyl)-2,3-dihydro[1,3]thiazolo[3,2-a]pyrimidin-4-ium iodide.

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Authors and Affiliations

  1. South Ural State University, pr. imeni Lenina 76, Chelyabinsk, 454071, Russia

    T. V. Frolova & D. G. Kim

  2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990, Russia

    P. A. Slepukhin

Authors
  1. T. V. Frolova
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  2. D. G. Kim
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  3. P. A. Slepukhin
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Correspondence to T. V. Frolova.

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Original Russian Text © T.V. Frolova, D.G. Kim, P.A. Slepukhin, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 9, pp. 1356–1358.

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Frolova, T.V., Kim, D.G. & Slepukhin, P.A. Iodocyclization of 2-[allyl(methallyl)sulfanyl]-6-(trifluoromethyl)pyrimidin-4(3H)-ones. Russ J Org Chem 52, 1344–1347 (2016). https://doi.org/10.1134/S1070428016090165

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  • DOI: https://doi.org/10.1134/S1070428016090165

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