Abstract
In reaction of 6-aminouracyles with ethyl oxochloroacetate ethyl 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetates were obtained, which by further reaction with various amines afforded oxo(pyrimidinyl)acetamides. According to the data of biological tests, the synthesized compounds showed low antibacterial and antitumor activity.
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Original Russian Text © S.P. Gasparyan, M.V. Alexanyan, G.K. Arutyunyan, А.H. Martirosyan, R.V. Paronikyan, H.M. Stepanyan, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 8, pp. 1186–1189.
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Gasparyan, S.P., Alexanyan, M.V., Arutyunyan, G.K. et al. N-substituted 2-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoacetamides. Russ J Org Chem 52, 1179–1182 (2016). https://doi.org/10.1134/S1070428016080145
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DOI: https://doi.org/10.1134/S1070428016080145