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Domino reactions of pyrazol-5-amines with arylglyoxals and malononitrile

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Abstract

Domino reactions of 3-methylpyrazol-5-amine and 1-phenyl-3-methylpyrazol-5-amine with arylglyoxal hydrates and malononitrile in alcohol proceed regioselectively and lead to the formation of 6-aminopyrazolo[3,4-b]pyridine-5-carbonitrile.

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Authors and Affiliations

  1. Research and Development Complex “Institute of Single Crystals”, National Academy of Sciences of Ukraine, Kharkiv, Ukraine

    O. N. Petrova, V. V. Lipson, L. L. Zamigajlo, M. G. Shirobokova & V. I. Musatov

  2. Danilevskii Institute of the Endocrinal Pathology Problems, National Academy of Medicinal Sciences of Ukraine, ul. Alchevskikh 10, Kharkiv, 61002, Ukraine

    V. V. Lipson

  3. Karazin Kharkiv National University, Kharkiv, Ukraine

    V. V. Lipson & D. A. Dmitrienko

Authors
  1. O. N. Petrova
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  2. V. V. Lipson
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  3. L. L. Zamigajlo
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  4. M. G. Shirobokova
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  5. V. I. Musatov
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  6. D. A. Dmitrienko
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Corresponding author

Correspondence to V. V. Lipson.

Additional information

Original Russian Text © O.N. Petrova, V.V. Lipson, L.L. Zamigajlo, M.G. Shirobokova, V.I. Musatov, D.A. Dmitrienko, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 8, pp. 1176–1180.

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Petrova, O.N., Lipson, V.V., Zamigajlo, L.L. et al. Domino reactions of pyrazol-5-amines with arylglyoxals and malononitrile. Russ J Org Chem 52, 1168–1172 (2016). https://doi.org/10.1134/S1070428016080121

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  • DOI: https://doi.org/10.1134/S1070428016080121

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