Abstract
Michael addition of ethyl N-arylmalonamates to ethyl 2-(ethoxymethylidene)-3-oxobutanoate in ethanol in the presence of triethylamine at room temperature afforded the corresponding adducts which underwent cyclization to diethyl 1-aryl-6-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxylates in 17–65% yield. N-Alkylmalonamic acid esters failed to react with ethyl 2-(ethoxymethylidene)-3-oxobutanoate under analogous conditions.
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Original Russian Text © S.S. Hayotsyan, A.H. Hasratyan, A.A. Sargsyan, A.Kh. Khachatryan, A.E. Badasyan, S.G. Kon’kova, M.S. Sargsyan, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 6, pp. 871–875.
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Hayotsyan, S.S., Hasratyan, A.H., Sargsyan, A.A. et al. Synthesis of substituted 1,2-dihydropyridines by reaction of ethyl N-arylmalonamates with ethyl 2-(ethoxymethylidene)-3-oxobutanoate. Russ J Org Chem 52, 857–861 (2016). https://doi.org/10.1134/S1070428016060166
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DOI: https://doi.org/10.1134/S1070428016060166