Synthesis of 1-substituted 5-alkyl(aryl)-1,3-dihydro-2H-pyrrol-2-ones. Azocoupling with diazonium salts
Reactions of 5-alkyl- and 5-aryl-3H-furan-2-ones with 1,3- and 1,4-binucleophiles of aromatic series were carried out for the first time under various conditions. In the presence of a base the reaction resulted in 1-R-1,3-dihydro-2Н-pyrrol-2-ones, under milder conditions intermediates were isolated, 4-aryl-4-oxobutanamides. The structure of the latter was proved by spectral methods. By an example of 1-R-1,3-dihydro-2Н-pyrrol-2-ones the possibility was demonstrated of their functionalization via introducing an aryldiazenyl fragment.
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- 4.Konovalova, V.V., Shklyaev, Yu.V., and Maslivets, A.N., Arkivoc, 2015, vol. i, p. 48.Google Scholar