Abstract
A procedure has been developed for the synthesis of ethyl 1-benzoyl-4-chloro-2-phenylpyrrolidine-2-carboxylate and 4-chloro-5-oxo-1,2-diphenyl-, 1-benzoyl-2-(2-benzyloxy-5-chlorophenyl)-4-chloro-, and 1-benzoyl-2-(4-benzyloxyphenyl)-4-chloropyrrolidine-2-carbonitriles in high yields via intramolecular cyclization of the corresponding 2,3-dichloropropionamides under conditions of phase-transfer catalysis.
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Original Russian Text © S.P. Gasparyan, M.V. Alexanyan, G.K. Harutyunyan, A.H. Martirosyan, R.A. Tamazyan, A.G. Ayvazyan, H.A. Panosyan, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 6, pp. 870–876.
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Gasparyan, S.P., Alexanyan, M.V., Harutyunyan, G.K. et al. Synthesis and X-ray analysis of 2-aryl-4-chloropyrrolidine-2-carbonitrile derivatives. Russ J Org Chem 51, 853–859 (2015). https://doi.org/10.1134/S1070428015060068
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DOI: https://doi.org/10.1134/S1070428015060068