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Synthesis and properties of new benzo[4,5]thiazolo[3,2-a]pyrimidine derivatives

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Abstract

Heating a mixture of substituted malonic esters and 6-methoxy-1,3-benzothiazolyl-2-amine afforded new derivatives of benzo[4,5]thiazolo[3,2-a]pyrimidine, 3-substituted 2-hydroxy-4H-benzo[4,5]-thiazolo[3,2-a]pyrimidine-4-ones. The choice between the possible tautomers was carried out basing on the X-ray diffraction analysis of 3-formyl-2-chloro derivative synthesized by formylation of unsubstituted heterocycle by Vilsmeier reaction.

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Authors and Affiliations

  1. Scientific and Technologic Center of Organic and Pharmaceutical Chemistry National Academy of Sciences of Armenia, Mnjoayan Institute of Fine Organic Chemistry, pr. Azatutyan 26, Yerevan, 0014, Armenia

    A. A. Harutyunyan, R. V. Paronikyan, H. M. Stepanyan, R. S. Sukasyan & A. S. Grigoryan

  2. Center of Study of Molecular Structure, National Academy of Sciences of Armenia, Yerevan, Armenia

    G. A. Panosyan, S. G. Chishmarityan, R. A. Tamazyan & A. G. Aivazyan

Authors
  1. A. A. Harutyunyan
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  2. G. A. Panosyan
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  3. S. G. Chishmarityan
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  4. R. A. Tamazyan
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  5. A. G. Aivazyan
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  6. R. V. Paronikyan
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  7. H. M. Stepanyan
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  8. R. S. Sukasyan
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  9. A. S. Grigoryan
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Corresponding author

Correspondence to A. A. Harutyunyan.

Additional information

Original Russian Text © A.A. Harutyunyan, G.A. Panosyan, S.G. Chishmarityan, R.A. Tamazyan, A.G. Aivazyan, R.V. Paronikyan, H.M. Stepanyan, R.S. Sukasyan, A.S. Grigoryan, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 5, pp. 727–730.

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Harutyunyan, A.A., Panosyan, G.A., Chishmarityan, S.G. et al. Synthesis and properties of new benzo[4,5]thiazolo[3,2-a]pyrimidine derivatives. Russ J Org Chem 51, 711–714 (2015). https://doi.org/10.1134/S107042801505022X

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  • DOI: https://doi.org/10.1134/S107042801505022X

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