Abstract
Reaction of 11H-indeno[1,2-b]quinoxalin-2-one with semi(thiosemi)carbazides in ethanol resulted in semi(thiosemi)carbazones which at boiling in acetic anhydride underwent cylization yielding N-{3′-acetyl-3′H-spiro[indeno[1,2-b]quinoxalin-11,2′-[1,3,4]oxa(thia)diazol]-5′-yl}acetamides. Aldol crotonic condensation of 11H-indeno[1,2-b]quinoxalin-2-one with methyl N-(4-acetylphenyl)carbamate afforded the corresponding chalcone that at boiling in anhydrous ethanol with hydrazine hydrate for 1 h formed a spiro compound with a pyrazole ring. Five-component condensation of ninhydrin, 1,2-phenylenediamine, sarcosine, malononitrile (or ethyl cyanoacetate), and 4-formylphenyl N-phenylcarbamate in a mixture EtOH — [bmim]Br led to the formation of 4-{3′,3′-dicyano(or 3′-ethoxycarbonyl-3′-cyano)-1′-methylspiro[indeno[1,2-b]quinoxaline-11,2′-pyrrolidin]-4′-yl}phenyl N-phenylcarbamates.
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Original Russian Text © A.V. Velikorodov, N.N. Stepkina, E.A. Shustova, V.A. Ionova, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 5, pp. 693–697.
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Velikorodov, A.V., Stepkina, N.N., Shustova, E.A. et al. Synthesis of new spiro compounds proceeding from 11H-Indeno[1,2-b]quinoxalin-2-one. Russ J Org Chem 51, 674–679 (2015). https://doi.org/10.1134/S1070428015050164
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DOI: https://doi.org/10.1134/S1070428015050164