Skip to main content
SpringerLink
Log in

One-step synthesis of pyrido[2,3-d]pyrimidines, amides, and benzoxazolylethylpyrimidine by condensation of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with aromatic amines in polyphosphoric acid

  • Published:
Russian Journal of Organic Chemistry Aims and scope Submit manuscript

Abstract

Depending on the reactant structure, reactions of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with 2-aminopyridine, p-toluidine, and 2-aminophenol in polyphosphoric acid afforded the corresponding N-(pyridin-2-yl)propanamides, 5-[2-(benzoxazol-2-yl)ethyl]pyrimidine, and pyrido[2,3-d]pyrimidinones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Harutyunyan, A.A., Khim. Zh. Arm., 2012, vol. 65, p. 257.

    CAS  Google Scholar 

  2. Harutyunyan, A.A., Russ. J. Org. Chem., 2014, vol. 50, p. 94.

    Article  CAS  Google Scholar 

  3. Harutyunyan, A.A., Panosyan, H.A., Tamazyan, R.A., and Ayvazyan, A.G., Khim. Zh. Arm., 2014, vol. 67, p. 214.

    CAS  Google Scholar 

  4. Palatinus, L. and Chapuis, G., J. Appl. Crystallogr., 2007, vol. 40, p. 786.

    Article  CAS  Google Scholar 

  5. Petricek, V., Dusek, M., and Palatinus, L., JANA. Structure Determination Software Programs, Praha, Czech Republic: Institute of Physics, 2006.

    Google Scholar 

  6. Hullar, T.L. and French, W.C., J. Med. Chem., 1969, vol. 12, p. 424.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, pr. Azatutyan 26, Yerevan, 0014, Armenia

    A. A. Harutyunyan

  2. Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, pr. Azatutyan 26, Yerevan, 0014, Armenia

    H. A. Panosyan, S. G. Chishmarityan, R. A. Tamazyan & A. G. Ayvazyan

Authors
  1. A. A. Harutyunyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. A. Panosyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. G. Chishmarityan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. A. Tamazyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. G. Ayvazyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Harutyunyan.

Additional information

Original Russian Text © A.A. Harutyunyan, H.A. Panosyan, S.G. Chishmarityan, R.A. Tamazyan, A.G. Ayvazyan, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 3, pp. 373–376.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Harutyunyan, A.A., Panosyan, H.A., Chishmarityan, S.G. et al. One-step synthesis of pyrido[2,3-d]pyrimidines, amides, and benzoxazolylethylpyrimidine by condensation of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with aromatic amines in polyphosphoric acid. Russ J Org Chem 51, 357–360 (2015). https://doi.org/10.1134/S1070428015030112

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070428015030112

Keywords

Search

Navigation