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Some regularities of the synthesis of ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates


Features of amidoximes reactions with ethyl chlorooxalate in a wide range of solvents at the use of a number of bases were investigated. An efficient preparation method for ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates in acetonitrile in the presence of triethylamine was developed.

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Correspondence to E. R. Kofanov.

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Original Russian Text © A.A. Voronova, S.V. Baikov, G.G. Krasovskaya, A.V. Kolobov, E.R. Kofanov, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 11, pp. 1694–1697.

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Voronova, A.A., Baikov, S.V., Krasovskaya, G.G. et al. Some regularities of the synthesis of ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates. Russ J Org Chem 50, 1683–1686 (2014).

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