Abstract
Copper(I)-catalyzed hetarylation of a series of polyamines and of 4,7,10-trioxatridecane-1,13-diamine with halothiophenes has been studied with a view to obtaining the corresponding N,N′-dihetaryl derivatives. The target products can be obtained using both 3-iodothiophene in the presence of CuI/L-proline/EtCN or CuI/N,N-dimethylglycine/EtCN as catalytic system and 3-bromothiophene in the system CuI/2-(2-methyl-1-oxopropyl)cyclohexanone/DMF. The latter system is also suitable for the hetarylation of 4,7,10-trioxatridecane-1,13-diamine with 3-iodothiophene. In some cases, N-(thiophen-3-yl) derivatives have also been isolated.
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Original Russian Text © M.V. Anokhin, A.D. Averin, S.P. Panchenko, O.A. Maloshitskaya, I.P. Beletskaya, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 7, pp. 943–947.
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Anokhin, M.V., Averin, A.D., Panchenko, S.P. et al. Copper(I)-catalyzed amination of halothiophenes with polyamines. Russ J Org Chem 50, 923–927 (2014). https://doi.org/10.1134/S107042801407001X
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DOI: https://doi.org/10.1134/S107042801407001X