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Perfluoro(1,2-epoxycyclohexane) in the synthesis of fluorinated heterocycles

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Abstract

Perfluoro(1,2-epoxycyclohexane) readily reacts with bifunctional nucleophiles (urea, thiourea, and benzene-1,2-diamine) via opening of the oxirane ring and subsequent heterocyclization to give fluorinated benzimidazole, 1,3-benzothiazole, and phenazine derivatives, respectively.

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Authors and Affiliations

  1. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990, Russia

    T. I. Filyakova, A. Ya. Zapevalov, M. I. Kodess, P. A. Slepukhin & V. I. Saloutin

Authors
  1. T. I. Filyakova
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  2. A. Ya. Zapevalov
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  3. M. I. Kodess
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  4. P. A. Slepukhin
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  5. V. I. Saloutin
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Corresponding author

Correspondence to T. I. Filyakova.

Additional information

Dedicated to Full Member of the Russian Academy of Sciences O.N. Chupakhin on his 80th anniversary

Original Russian Text © T.I. Filyakova, A.Ya. Zapevalov, M.I. Kodess, P.A. Slepukhin, V.I. Saloutin, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 6, pp. 870–873.

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Filyakova, T.I., Zapevalov, A.Y., Kodess, M.I. et al. Perfluoro(1,2-epoxycyclohexane) in the synthesis of fluorinated heterocycles. Russ J Org Chem 50, 854–857 (2014). https://doi.org/10.1134/S1070428014060177

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  • DOI: https://doi.org/10.1134/S1070428014060177

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