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Synthesis of new 2-substituted 6,7-dimethoxy-1-(methylcarbamoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolines

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Abstract

New 2-(heterylmethyl) derivatives were synthesized from 6,7-dimethoxy-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide and heterylmethyl chlorides. The reactions of 2-chloroacetyl-substituted tetrahydroisoquinoline with versatile secondary amines and heterylthiols afforded the corresponding 2-aminoacetyl and 2-(heterylsulfanylacetyl) derivatives of tetrahydroisoquinoline series.

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  2. Agekyan, A.A., Arakelyan, E.A., Panosyan, G.A., Khachatryan, A.G., and Markaryan, E.A., Khim. Geterotsikl. Soedin., 2009, p. 1338.

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Authors and Affiliations

  1. R&D Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Mndzhoyan Institute of Fine Organic Chemistry, Yerevan, 0014, Armenia

    A. A. Aghekyan, G. G. Mkryan & E. A. Markaryan

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  1. A. A. Aghekyan
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  2. G. G. Mkryan
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  3. E. A. Markaryan
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Correspondence to A. A. Aghekyan.

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Original English Text © A.A. Aghekyan, G.G. Mkryan, E.A. Markaryan, 2013, published in Zhurnal Organicheskoi Khimii, 2013, Vol. 49, No. 11, pp. 1651–1654.

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Aghekyan, A.A., Mkryan, G.G. & Markaryan, E.A. Synthesis of new 2-substituted 6,7-dimethoxy-1-(methylcarbamoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolines. Russ J Org Chem 49, 1632–1636 (2013). https://doi.org/10.1134/S1070428013110122

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  • DOI: https://doi.org/10.1134/S1070428013110122

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