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Halocyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

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Abstract

Cyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione by the action of iodine, bromine, or sulfuryl chloride gave 2-(2-{4-[4,5-dihydro-5-(halomethyl)-thiazol-2-yl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione hydrohalides which were converted into 2-{2-[4-(5-methylthiazol-2-yl)piperazin-1-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02660, Ukraine

    Yu. L. Zborovskii, V. V. Orysyk & V. I. Staninets

  2. Institute of General and Inorganic Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    V. V. Bon’

Authors
  1. Yu. L. Zborovskii
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  2. V. V. Orysyk
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  3. V. I. Staninets
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  4. V. V. Bon’
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Correspondence to Yu. L. Zborovskii.

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Original Russian Text © Yu.L. Zborovskii, V.V. Orysyk, V.I. Staninets, V.V. Bon’, 2011, published in Zhurnal Organicheskoi Khimii, 2011, Vol. 47, No. 6, pp. 865–869.

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Zborovskii, Y.L., Orysyk, V.V., Staninets, V.I. et al. Halocyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. Russ J Org Chem 47, 881–885 (2011). https://doi.org/10.1134/S107042801106008X

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  • DOI: https://doi.org/10.1134/S107042801106008X

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