Abstract
Reactions of 1,3-bis(bromopentyl)-5(6)-substituted uracyls with a series of five-membered heterocycles containing in the ring N, S, or O atoms and a mercapto group as a substituent at the carbon atom of the ring afforded uracyl derivatives of acyclic and macrocyclic structure with 2-thiobenzoxazole, 2-thio-5-methyl-1,3,4-thiadiazole, 2-thiobenzimidazole, and 2,5-dithio-1,3,4-thiadiazole fragments. N atoms of benzoxazole and imidazole fragments of compounds obtained undergo alkylation and quaternization with alkyl iodides and alkyl tosylates.
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Original Russian Text © E.S. Krylova, V.E. Semenov, I.V. Galyametdinova, V.D. Akamsin, D.R. Sharafutdinova, V.S. Reznik, 2011, published in Zhurnal Organicheskoi Khimii, 2011, Vol. 47, No. 5, pp. 741–747.
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Krylova, E.S., Semenov, V.E., Galyametdinova, I.V. et al. Uracyl derivatives functionalized with N-, S-, O-heterocycles. Russ J Org Chem 47, 746–752 (2011). https://doi.org/10.1134/S1070428011050149
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DOI: https://doi.org/10.1134/S1070428011050149