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Ionic liquid-phase organic synthesis (IoLiPOS) methodology applied to cross aldol reaction

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Abstract

Cross aldol reaction in task-specific ionic liquids was developed. Ionic liquid-phase bound aldehyde reacted with various ketones (acetone, cyclopentanone, and butan-2-one) with l-proline as catalyst to afford various ionic liquid-phase supported aldols in yields ranging from 81 to 99%. Detachment of the aldol in MeOH was realized by transesterification using 15% of MeONa. The structure of intermediates in each step was verified by spectroscopic analysis.

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Authors and Affiliations

  1. Laboratoire Sciences Chimiques de Rennes, UMR CNRS 6226, Groupe Ingénierie Chimique & Molécules pour le Vivant (ICMV), Bât. 10A, Campus de Beaulieu, Université de Rennes 1, Avenue du Général Leclerc, CS 74205, 35042, RENNES Cedex, France

    H. Hakkou, D. Carrié, L. Paquin & J. -P. Bazureau

Authors
  1. H. Hakkou
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  2. D. Carrié
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  3. L. Paquin
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  4. J. -P. Bazureau
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Corresponding author

Correspondence to J. -P. Bazureau.

Additional information

Published in Russian in Zhurnal Organicheskoi Khimii, 2011, Vol. 47, No. 3, pp. 377–379.

The text was submitted by the authors in English.

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Hakkou, H., Carrié, D., Paquin, L. et al. Ionic liquid-phase organic synthesis (IoLiPOS) methodology applied to cross aldol reaction. Russ J Org Chem 47, 371–373 (2011). https://doi.org/10.1134/S1070428011030079

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  • DOI: https://doi.org/10.1134/S1070428011030079

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